Effects of a New Antitumor Agent, Epipodophyllotoxin, on Growth and Chromosomes in Human Hematopoietic Cell Lines1
نویسندگان
چکیده
and a high incidence of cells with chromosome aberrations. The generation times of the lines, estimated by pulse labeling with thymidine-3H, ranged from 19 to 25 hr. Most of the aberrations observed in culture continuously treated with VP-16 were of the chromatid type. On the basis of generation times, types of aberrations, and data obtained in a culture pulsed with thymidine-3H and continuously treated with VP-16, it seems that aberrations were induced in the G2 and S phases of the cell cycle. Cultures were also pulse treated with VP-16 for 1 hr at either IO"4 or 10~5M.
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